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Immobilization of single strand DNA on solid support

Recently we have demonstrated the immobilization of single strand DNA onto a solid support by electrostatic interaction with a polycation poly(allylamine hydrochloride) (PAH). The films were analyzed by UV–vis spectroscopy. We have shown that single stranded DNA gets immobilized on the PAH backbone of Layer-by-Layer (LbL) films when the films are fabricated above the melting temperature of DNA. Singly stranded DNA immobilized in the LbL films is not restored into double stranded DNA at room temperature.

Read the article here at Chemical Physics Letters


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